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國立陽明大學生理學科暨研究所

歡迎來到國立陽明大學生理學科暨研究所

高毓儒

個人資料 研究方向 代表著作 五年內執行計畫 實驗室成員  (2019.07.24  update)

姓名

高毓儒

高毓儒

職稱 教授
通訊電話 02-2826-7086
傳真號碼 02-2826-4049
電子信箱 yrkou@ym.edu.tw
學歷
1989 PhD Department of Physiology and Biophysics, University of Kentucky, Kentucky
1980 BS Bachelor of Science, Department of Biology, Tunghai  University, R.O.C

經歷

國立陽明大學醫學院生理學研究所教授(1997-至今)

國立陽明大學醫學院急重症醫學研究所教授(2008-至今)

行政院國科會生物處形態及生理醫學學門召集人(2008-2011)

國立陽明大學醫學院生理學研究所副教授(1991-1997)

美國凱斯西儲大學醫學院呼吸重症中心研究員(1989-1991)

專長

呼吸生理學、分子生物學、急重病醫學、醫學流行病學、臨床醫學研究

研究方向

主要的研究興趣是:

(1)肺細胞發炎反應與凋亡的調控-以細胞培養、各種蛋白質定量、免疫染色、PCR、微陣列基因分析、基因轉殖等分子細胞生物學的技術進行研究。用上皮、血管內皮、巨噬細胞等肺細胞為研究題材。

(2)多種肺損傷與肺發炎的成因與治療-以各種蛋白質定量、免疫染色、PCR、組織切片等方法進行研究。用大鼠與小鼠為研究題材。

(3)急重症醫學及呼吸治療-以呼吸生理訊號及肺功能機械學測量、各種蛋白質定量、免疫染色、PCR、組織切片等方法進行研究。用大鼠與小鼠為研究題材,並操作人體實驗。

(4)醫學流行病學及臨床醫學研究

目前(20198)實驗室現有1位碩士班研究生,1位基礎醫學組博士班研究生,8位臨床醫學組博士班研究生及2位專任研究助理。

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代表著作(五年內)
1 Chen PK, Shih CC, Lin FC, Perng DW, Chou KT, Kou YR*, Ko HK. Prolonged use of noninvasive positive pressure ventilation after extubation among patients in the intensive care unit following cardiac surgery: The predictors and its impact on patient outcome. Sci Rep. 2019 Jul 2;9(1):9539.
2 Su KC, Ko HK, Chou KT, Hsiao YH, Su VY, Perng DW, Kou YR*. An accurate prediction model to identify undiagnosed at-risk patients with COPD: a cross-sectional case-finding study. NPJ Prim Care Respir Med. 2019 May 28;29(1):22.
3 Chen YC, Yu WK, Ko HK, Pan SW, Chen YW, Ho LI, Bien MY, Wang JH, Chan YJ, Kou YR*. Post-intensive care unit respiratory failure in older patients liberated from intensive care unit and ventilator: The predictive value of the National Early Warning Score on intensive care unit discharge. Geriatr Gerontol Int. 2019 Apr;19(4):317-322.
4 Lin AH, Liu MH, Ko HK, Perng DW, Lee TS, Kou YR*. Menthol Cigarette Smoke Induces More Severe Lung Inflammation Than Non-menthol Cigarette Smoke Does in Mice With Subchronic Exposure - Role of TRPM8. Front Physiol. 2018 Dec 18;9:1817.
5 Hsiao YH, Tseng CM, Su KC, Chen WC, Wu MT, Wu YC, Chang SC, Lee YC, Kou YR*, Perng DW. Glycopyrronium bromide inhibits lung inflammation and small airway remodeling induced by subchronic cigarette smoke exposure in mice. Respir Physiol Neurobiol. 2018 Feb;249:16-22.
6 Pan SW, Yen YF, Kou YR, Chuang PH, Su VY, Feng JY, Chan YJ, Su WJ. The Risk of TB in Patients With Type 2 Diabetes Initiating Metformin vs Sulfonylurea Treatment. Chest. 2018 Jun;153(6):1347-1357.
7 Su KC, Kou YR, Lin FC, Wu CH, Feng JY, Huang SF, Shiung TF, Chung KC, Tung YH, Yang KY, Chang SC. A simplified prevention bundle with dual hand hygiene audit reduces early-onset ventilator-associated pneumonia in cardiovascular surgery units: An interrupted time-series analysis. PLoS One. 2017 Aug 2;12(8):e0182252.
8 Pan SW, Yen YF, Kou YR, Chuang PH, Feng JY, Chan YJ, Su WJ. The impact of cancer development on the risk of mycobacterial diseases among rheumatoid arthritis patients. Epidemiol Infect. 2017 Sep;145(12):2482-2490.
9 Lin CH, Jeng MJ, Yang YC, Hsiao YH, Kou YR*. Comparison of different dosing strategies of intratracheally instilled budesonide on meconium injured piglet lungs. Pediatr Pulmonol. 2017 Jul;52(7):891-899.
10 Lin AH, Liu MH, Ko HB, Perng DW, Lee TS, Kou YR*. Inflammatory Effects of Menthol vs. Non-menthol Cigarette Smoke Extract on Human Lung Epithelial Cells: A Double-Hit on TRPM8 by Reactive Oxygen Species and Menthol. Front Physiol. 2017 Apr 27;8:263.
11 Tsao PC, Lee YS, Jeng MJ, Hsu JW, Huang KL, Tsai SJ, Chen MH, Soong WJ, Kou YR*. Additive effect of congenital heart disease and early developmental disorders on attention-deficit/hyperactivity disorder and autism spectrum disorder: a nationwide population-based longitudinal study. Eur Child Adolesc Psychiatry. 2017 Nov;26(11):1351-1359.
12 Liu MH, Lin AH, Ko HK, Perng DW, Lee TS, Kou YR*. Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol. Front Physiol. 2017 Mar 31;8:193.
13 Su KC, Chou KT, Hsiao YH, Tseng CM, Su VY, Lee YC, Perng DW, Kou YR*. Measuring (1,3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study. BMC Infect Dis. 2017 Apr 8;17(1):252.
14 Yang CH, Shen YJ, Lai CJ, Kou YR*. Inflammatory Role of ROS-Sensitive AMP-Activated Protein Kinase in the Hypersensitivity of Lung Vagal C Fibers Induced by Intermittent Hypoxia in Rats. Front Physiol. 2016 Jun 27;7:263.
15 Zhao JF, Shyue SK, Kou YR, Lu TM, Lee TS. Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation. Int J Biol Sci. 2016 May 25;12(7):812-23.
16 Chan MC, Tseng JS, Hsu KH, Shih SJ, Yi CY, Wu CL, Kou YR*. A minimum blood glucose value less than or equal to 120 mg/dL under glycemic control is associated with increased 14-day mortality in nondiabetic intensive care unit patients with sepsis and stress hyperglycemia. J Crit Care. 2016 Aug;34:69-73.
17 Chan MC, Lin CH, Kou YR*. Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort study. Int J Chron Obstruct Pulmon Dis. 2016 May 18;11:1053-9.
18 Yang CH, Zhuang WL, Shen YJ, Lai CJ, Kou YR*. NADPH Oxidase-Derived ROS Induced by Chronic Intermittent Hypoxia Mediates Hypersensitivity of Lung Vagal C Fibers in Rats. Front Physiol. 2016 May 9;7:166.
19 Yu YB, Su KH, Kou YR, Guo BC, Lee KI, Wei J, Lee TS. Role of transient receptor potential vanilloid 1 in regulating erythropoietin-induced activation of endothelial nitric oxide synthase. Acta Physiol (Oxf). 2017 Feb;219(2):465-477.
20 Tseng YH, Ko HK, Tseng YC, Lin YH, Kou YR*. Atrial Fibrillation on Intensive Care Unit Admission Independently Increases the Risk of Weaning Failure in Nonheart Failure Mechanically Ventilated Patients in a Medical Intensive Care Unit: A Retrospective Case-Control Study. Medicine (Baltimore). 2016 May;95(20):e3744.
21 Lin CH, Jeng MJ, Kuo BI, Kou YR*. Effects of Surfactant Lavage Combined With Intratracheal Budesonide Instillation on Meconium-Injured Piglet Lungs. Pediatr Crit Care Med. 2016 Jun;17(6):e287-95.
22 Pan SW, Kou YR, Hu TM, Wu YC, Lee YC, Feng JY, Su WJ. Assessment of latent tuberculosis infection in psychiatric inpatients: A survey after tuberculosis outbreaks. J Microbiol Immunol Infect. 2016 Aug;49(4):575-83.
23 Pan SW, Yen YF, Feng JY, Su VY, Kou YR, Su WJ. The Risk of Depressive Disorder Among Contacts of Tuberculosis Patients in a TB-endemic Area: A Population-based Cohort Study. Medicine (Baltimore). 2015 Oct;94(43):e1870.
24 Lin AH, Liu MH, Ko HK, Perng DW, Lee TS, Kou YR*. Lung Epithelial TRPA1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke: The Role of Influxed Ca²⁺. Mediators Inflamm. 2015;2015:148367.
25 Yu WK, Ko HK, Ho LI, Wang JH, Kou YR*. Synergistic impact of acute kidney injury and high level of cervical spinal cord injury on the weaning outcome of patients with acute traumatic cervical spinal cord injury. Injury. 2015 Jul;46(7):1317-23.
26 Liu BY, Lin YJ, Lee HF, Ho CY, Ruan T, Kou YR*. Menthol suppresses laryngeal C-fiber hypersensitivity to cigarette smoke in a rat model of gastroesophageal reflux disease: the role of TRPM8. J Appl Physiol (1985). 2015 Mar 1;118(5):635-45.
27 Ko HK, Lee HF, Lin AH, Liu MH, Liu CI, Lee TS, Kou YR*. Regulation of Cigarette Smoke Induction of IL-8 in Macrophages by AMP-activated Protein Kinase Signaling. J Cell Physiol. 2015 Aug;230(8):1781-93.
28 Liu MH, Lin AH, Lu SH, Peng RY, Lee TS, Kou YR*. Eicosapentaenoic acid attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling. Front Physiol. 2014 Nov 14;5:440.
29 Zhao JF, Hsiao SH, Hsu MH, Pao KC, Kou YR, Shyue SK, Lee TS. Di-(2-ethylhexyl) phthalate accelerates atherosclerosis in apolipoprotein E-deficient mice. Arch Toxicol. 2016 Jan;90(1):181-90.
30 Chan MC, Tseng JS, Chiu JT, Hsu KH, Shih SJ, Yi CY, Wu CL, Kou YR*. Prognostic value of plateau pressure below 30 cm H2O in septic subjects with acute respiratory failure. Respir Care. 2015 Jan;60(1):12-20.
31 Fan WJ, Chen SC, Hsieh TH, Lai CH, Lin YS, Peng CW, Kou YR*. Influence of serotonergic mechanisms on the urine flow rate in male rats. Am J Physiol Regul Integr Comp Physiol. 2014 Nov 15;307(10):R1239-50.
32 Liu MH, Lin AH, Lee HF, Ko HK, Lee TS, Kou YR*. Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling. Mediators Inflamm. 2014;2014:651890.
33 Ruan T, Lin YJ, Hsu TH, Lu SH, Jow GM, Kou YR*. Sensitization by pulmonary reactive oxygen species of rat vagal lung C-fibers: the roles of the TRPV1, TRPA1, and P2X receptors. PLoS One. 2014 Apr 3;9(4):e91763.
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五年內執行計畫

1.科技部  由香煙煙霧所誘導的肺非對稱二甲基精氨酸可促進支氣管周圍纖維化及肺內皮細胞功能障礙並加速動脈粥樣硬化的形成:活體及離體的研究 (2018/08/01~2021/07/31)( 主持人)

2.科技部   香煙及薄荷香煙刺激肺細胞的非神精性瞬態電壓感受器陽離子通道M類第8型導致肺發炎及肺氣腫 (2015/08/01~2018/07/31)( 主持人)

3.科技部  肺阻塞合併胃食道逆流患者之氣道發炎: 膽酸嗆入之角色及膽酸與自毒素-溶血磷脂酸發炎路徑之聯結 (2019/08/01~2020/07/31)(共同主持人)

4.科技部  探討自毒素-溶血磷脂酸路徑機轉在香菸刺激引起氣道發炎之角色-以鼠肺切片進行之研究  (2017/08/01~2018/07/31)(共同主持人)

5.科技部  比較類固醇合併長效乙二型作用劑或長效乙二型作用劑合併長效抗毒蕈鹼劑在香菸萃取物刺激後的支氣管收縮與發炎反應之療效-以鼠肺切片進行之研究  (2016/08/01~2017/07/31)(共同主持人)

實驗室成員

碩士班:李曉函

博士班(基礎生理組):張崇銘

博士班(臨床生理組)蕭逸涵、曾敬閔、曹珮真、吳崑明、詹明澄、王友明、余文光、蘇剛正

研究助理:許慧卿鄒喬婷

 

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