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國立陽明大學生理學科暨研究所

歡迎來到國立陽明大學生理學科暨研究所

吳莉玲

 

姓名 吳莉玲  

 

職稱 助理教授
通訊電話 02-2826-7365
傳真號碼 02-2826-4049
電子信箱  wuliling@ym.edu.tw
學歷

國立台灣大學生理學科暨研究所博士(2008-2014

國立台灣大學生理學科暨研究所碩士(2002 

國立陽明大學護理系學士(1999

經歷

國立陽明大學醫學院生理學科暨生理學研究所助理教授(Aug,2019-迄今) 

國立臺灣大學臨床醫學研究所博士後研究員(Sep,2014-Jul,2019) 

國立臺灣大學生理學科暨研究所助教(Jan,2002-Feb,2008) 

康寧護專兼任講師(Jan,2002-Feb,2004) 

台北榮民總醫院兼任及專任研究助理(Jan,1998-Dec,1999) 

專長

消化道生理學感染免疫學分子病毒學微生物學

研究方向
    本實驗室研究領域是以腸胃道生理學為主,目前研究計畫主要探討腸道菌透過腸-肝軸如何影響B型肝炎病毒持續性或清除感染之預後,主要目的是釐清其於免疫系統中innate myeloid cell和lymphoid cell所扮演的角色,以及腸道屏障功能的完整性,以期望了解腸道菌及其代謝產物如何影響肝臟免疫反應的完整訊息及機制,藉由此研究將有助於開發預防和治療先天免疫細胞相關肝病新穎和創新的策略,以期望未來可藉由細胞免疫療法來重新改編宿主的抗病毒免疫力,進而達成全面清除B型肝炎病毒,對未來B型肝炎的預防與治療提供新契機及新發現

    本實驗室透過疾病的動物模式及細胞分子層次,利用in vivoin vitro的實驗來完整及有系統的探討腸-肝軸 (gut-liver axis) 相關研究為主,目前實驗室已建立HBV-HDI mice, Germ free mice, CRISPR-Cas9 TLR4 mice, TLR4 mutant mice, intestinal obstruction等小鼠模式,並配合多種分子生物學的實驗技術,以進一步探討細胞分子的作用機轉。實驗技術包括:

  1. Intestinal, liver function and phenotype assay: ALT, AST, HBsAg, HBeAg, Anti-HBs, Anti-Hbe, Anti-Hbc, HBV DNA assay, bacterial translocation, H&E staining, isolation of total liver parenchymal and nonparenchymal cells and flow cytometry analysis.
  2. Biochemical technology: immunofluorescent staining, surface and intracellular staining for flow cytometric analysis and sorting, fluorescent in situ hybridization, ELISPOT, Adoptive transfer, hydrodynamic injection.
  3. Molecular biotechnology: RNA and DNA extraction, RT-PCR, siRNA knockdown, site directed mutagenesis, plasmid transfection, bacterial 16S rDNA sequencing, Temporal temperature gradient gel electrophoresis (TTGE), Southern Bolt, western blotting, Northern blotting. Gene expression profiles using NanoString or RNAseq.

歡迎具有積極主動、學習熱忱的同學加入腸胃道生理學的研究行列。

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學會會員

中國生理學會 (Chinese Physiological Society)

榮譽

研究獲獎

(1) 國際B型肝炎會議『博士後出國開會補助』,臺灣,2019

(2) 財團法人傑出人才基金會『博士後出國開會補助』,臺灣,2018。

(3) 國際B型肝炎會議『博士後出國開會補助』,美國,2018。

(4) 國際B型肝炎會議研討會『傑出海報獎』第一名,義大利,2018。

(5) 國際B型肝炎會議『博士後出國開會補助』,美國,2017。

(6) 國際B型肝炎會議研討會『傑出海報獎』第一名,美國,2017。

(7) 國立台灣大學『優秀研究生優秀著作獎』佳作,臺灣,2015

(8) 第三十屆全國生物醫學聯合學術年會『口頭論文競賽』傑出論文獎,臺灣,2015

(9) 第三十屆全國生物醫學聯合學術年會『口頭論文競賽』第一名,臺灣,2015

(10) 第二十九屆全國生物醫學聯合學術年會『口頭論文競賽』第一名,臺灣,2014

(11) 第一屆國立台灣大學『分子生醫影像攝影競賽』佳作,臺灣,2012

(12) 國立台灣大學『優秀研究生優秀著作獎』佳作,臺灣,2012

(13) 第二十七屆全國生物醫學聯合學術年會『壁報論文競賽』佳作,臺灣,2009

(14) 第二十五屆全國生物醫學聯合學術年會『口頭論文競賽』第一名,臺灣,2010

(15) 美國消化道疾病國際性研討會『傑出海報獎』,美國,2009

(16) 第二十四屆全國生物醫學聯合學術年會『壁報論文競賽』第一名,臺灣,2009

研究計畫

108/10/1-111/9/30: MOST 108-2320-B-010-045-MY3

腸道菌在肝臟先天免疫反應中對抗B型肝炎病毒所扮演的角色及其調控機制之探討

代表著作
1 Pin-Hung Lin, Chieh-Yu Liang, Bing-Yu Yao, Hui-Wen Chen, Ching-Fu Pan, Li-Ling Wu, Yi-Hsuan Lin, Yu-Sung Hsu, Yu-Han Liu, Pei-Jer Chen, Che-Ming Jack Hu* , Hung-Chih Yang *(2019) Robust resident memory T cells induced by a combinatorial nanoparticle vaccine confers cross-strain immunity against lethal influenza. Science Immunology(Submitted).IF 13.3
2 Tung-Ching Ho, Er-Yea Wang, Shiou-Hwei Yeh, Yi-Tzu Chen, Kun-Huei Yeh, Yung-Ming Jeng, Li-Ling Wu, Hsuan-Cheng Huang, Chia-Lang Hsu, Ding-Shinn Chen* and Pei-Jer Chen*. (2019) Complement C1q Mediating the Expansion of Periportal Hepatic Progenitor Cells in Inflammatory Liver. PNAS. (in press). IF 9.504
3 Li-Ling Wu, Hurng-Yi Wang, Pei-Jer Chen* (2019) Hydrodynamic HBV transfection in mouse models. International coalition to eliminate HBV(ICE-HBV).
https://ice-hbv.org/protocol/hydrodynamic-hbv-transfection-in-mouse-models/
4 Li-Ling Wu, Wei-Hao Peng, Hui-Lin Wu, Shi-Chuen Miaw, Shiou-Hwei Yeh, Hung-Chih Yang, Pei-Hsuan Liao, Jing-Shan Lin, Yan-Rong Chen, Yen-Tien Hong, Hurng-Yi Wang*, Pei-Jer Chen and Ding-Shinn Chen*, (2019) Ly6C+ Monocytes and Kupffer Cells Orchestrate Liver Immune Responses Against Hepatitis B Virus in Mice. Hepatology, 69(6):2364-2380.  https://doi.org/10.1002/hep.30510
IF 14.079 (Gastroenterology & Hepatology:5/80, 6.25%)
HEPATOLOGY HIGHLIGHTS | Hepatology, VOL . 69, NO. 6, 2019; https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.30775
5 Li-Ling Wu, Hurng-Yi Wang, Pei-Jer Chen*. (2017) Hydrodynamic HBV Transfection Mouse Model. Hepatitis B Virus Methods and Protocols-Methods in Molecular Biology (ISBN: 978-1-4939-6698-1). New York, USA: Springer New York. 2017: 227-235. DOI: 10.1007/978-1-4939-6700-1_19
6 Han-Hsuan Chou, Wei-Hung Chien, Li-Ling Wu, Chi-Hung Cheng, Chen-Han Chung, Jau-Haw Horng, Yen-Hsuan Ni, Hong-Tai Tseng, Dafei Wu, Xuemei Lu, Hurng-Yi Wang*, Pei-Jer Chen, and Ding-Shinn Chen* (2015) Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota. PNAS. 112(7):2175-80. https://doi.org/10.1073/pnas.1424775112
IF: 9.504 (MULTIDISCIPLINARY SCIENCES):5/64, 7.8125%)
7 You-Yu Lin, Chieh Liu, Wei-Hung Chien, Li-Ling Wu, YongTao, Dafei Wu, Xuemei Lu, Chia-Hung Hsieh, Pei-Jer Chen, Hurng-Yi Wang*, Jia-Horng Kao, Ding-Shinn Chen*. (2014) New insights into the evolutionary rate of hepatitis B virus at different biological scales. Journal of virology. 89(7):3512-22. DOI: 10.1128/JVI.03131-14
IF: 4.368 (VIROLOGY): 8/35, 22.86%)
8 Wei-Ting Kuo, Hsun-Yuan Yang, Chi-Yun Chen, Tsung-Chun Lee, Yin-Chung Au, Yen-Zhen Lu, Li-Ling Wu, Shu-Chen Wei, Yen-Hsuan Ni, John T Kung, Fuu Sheu, Long-Wei Lin, and Linda Chia-Hui Yu*. (2015) LPS receptor subunits play antagonistic roles in epithelial apoptosis and colonic carcinogenesis. Cell Death and Differentiation, 22(10):1590-604. https://www.nature.com/articles/cdd2014240
IF: 8.0 (BIOCHEMISTRY & MOLECULAR BIOLOGY): 26/293, 8.87%)
9 Linda Yu, Yi-An Shih, Li-Ling Wu, Yang-Ding Lin, Wei-Ting Kuo, Wei-Hao Peng, Kuo-Shyan Lu, Shu-Chen Wei, and Yen-Hsuan Ni*. (2014) Enteric dysbiosis promotes antibiotic-resistant bacterial infection: systemic dissemination of resistant and commensal bacteria through epithelial transcytosis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 307(8): G824-35. https://doi.org/10.1152/ajpgi.00070.2014
IF: 3.293 (PHYSIOLOGY): 22/83, 26.5%)
10 Li-Ling Wu, Wei-Hao Peng, Wei-Ting Kuo, Ching-Ying Huang, Yen-Hsuan Ni, Kuo-Shyan Lu, Jerrold R. Turner, and Linda C.H. Yu*. (2014) Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-gamma. American journal of pathology, 184(8):2260-74. DOI: https://doi.org/10.1016/j.ajpath.2014.05.003
IF: 4.069 (PATHOLOGY): 13/79, 16.46%)
11 Pin-Hung Lin, Chieh-Yu Liang, Bing-Yu Yao, Hui-Wen Chen, Ching-Fu Pan, Li-Ling Wu, Yi-Hsuan Lin, Yu-Sung Hsu, Yu-Han Liu, Pei-Jer Chen, Che-Ming Jack Hu* , Hung-Chih Yang *(2019) Robust resident memory T cells induced by a combinatorial nanoparticle vaccine confers cross-strain immunity against lethal influenza. Science Immunology (Submitted).
IF 13.3 https://www.nature.com/articles/cdd2014240
12 Li-Ling Wu, Hsin-Da Chiu, Wei-Hao Peng, Bor-Ru Lin, Kuo-Shyan Lu, Yen-Zhen Lu and Linda Chia-Hui Yu*. (2011) Epithelial inducible nitric oxide synthase causes bacterial translocation by impairment of enterocytic tight junctions via intracellular signals of Rho-associated kinase and protein kinase C zeta. Critical Care Medicine, 39 (9), 2087-2098.
IF: 6.312 (CRITICAL CARE MEDICINE: 4/27, 14.8%)
13 Chi-Chin Wu, Yen-Zhen Lu, Li-Ling Wu and Linda Chia-Hui Yu*. (2010) Role of myosin light chain kinase in intestinal epithelial barrier defects in a rat model of bowel obstruction. BMC Gastroenterology, 10: 39-50.  https://insights.ovid.com/pubmed?pmid=21552122
IF: 2.365 (GASTROENTEROLOGY & HEPATOLOGY:42/76, 55.3% )
14 Yih-Loong Lai*, Li-Ling Wu, Tai-Yin Lin, and Chien-He Lin. (2009) Mast cells in citric acid-induced airway constriction and cough. Chinese Journal of Physiology, 52 (5 Supplement): 332-338. https://www.ncbi.nlm.nih.gov/pubmed/20359123
IF: 1.163 (PHYSIOLOGY:73/83, 97.95%)
15 Li-Ling Wu, Fung-Jou Lu and Yih-Loong Lai*. (2004) Mast cells and reactive oxygen species in citric acid-induced airway constriction. Journal of applied physiology, 96: 1879-1885. DOI: 10.1152/japplphysiol.00999.2003
IF: 3.056 (SPORT SCIENCES:8/81, 9.88%)

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研討會摘要
1 Li-Ling Wu, Wei-Hao Peng, Wei-Ting Kuo, Ching-Ying Huang, Yen-Hsuan Ni, Kuo-Shyan Lu, Jerrold R. Turner, Linda C.H. Yu* (2014) Gut bacterial endocytosis is dependent on MLCK-activated brush border fanning by IFN. Gastroenterology 146 (5), S-697. DOI: https://doi.org/10.1016/S0016-5085(14)62533-6
2 Wei-Ting Kuo, Hsun-Yuan Yang, Chi-Yun Chen, Tsung-Chun Lee, Yen-Zhen Lu, Li-Ling Wu, Yen-Hsuan Ni, Shu-Chen Wei, Linda C.H. Yu* (2014) Opposing roles of CD14 and TLR4 in bacterial LPS-induced colonocytic apoptosis. Gastroenterology 146(5), S-294.
DOI: https://doi.org/10.1016/S0016-5085(14)61052-0
3 Wei-Ting Kuo, Hsun-Yuan Yang, Chi-Yun Chen, Tsung-Chun Lee, Yen-Zhen Lu, Li-Ling Wu, Yen-Hsuan Ni, Shu-Chen Wei, Linda C.H. Yu* (2014) Opposing roles of CD14 and TLR4 in bacterial LPS-induced colonocytic apoptosis. Gastroenterology 146(5), S-294.
DOI: https://doi.org/10.1016/S0016-5085(14)61052-0
4 Li-Ling Wu, Wei-Ting Kuo and Linda Chia-Hui Yu*. (2011) Epithelial MLCK-Dependent Bacterial Endocytosis by Enterocytes Precedes Paracellular Bacterial Flux in Bowel Obstruction. Gastroenterology,140(5), S63-S64.
DOI: https://doi.org/10.1016/S0016-5085(11)60259-X
5 Li-Ling Wu, Hsin-Da Chiu, Yen-Zhen Lu, and Linda Chia-Hui Yu*. (2010) Epithelial iNOS impairs tight junctions leading to bacterial translocation via PKCzeta activation and Rho/ROCK-dependent myosin light chain phosphorylation in obstructed guts. Gastroenterology 138 (5), Suppl 1, S-4.
DOI: https://doi.org/10.1016/S0016-5085(10)60018-2
6 Li-Ling Wu, Ching-Ying Huang, Yen-Zhen Lu, and Linda Chia-Hui Yu*. (2009) Epithelial MLCK and iNOS are involved in mucosal barrier defects and bacterial translocation induced by ileal obstruction. Gastroenterology 136 (5), Suppl 1, A410. DOI: https://doi.org/10.1016/S0016-5085(09)61886-2

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研討會專題報告
 
1 Li-Ling Wu, Hui-Lin Wu, Shih-Lun Chen, Yung-Tsung Li, Jing-Shan Lin, Hurng-Yi Wang, Pei-Jer Chen and Ding-Shinn Chen. Gut microbiota play a critical role in determining the outcome of hepatitis B virus infection. Oral Presentation. 2019 international HBV meeting: Mwelbourne, Australia. OCT 1~5, 2019.
2 Li-Ling Wu, Hui-Lin Wu, Shih-Lun Chen, Yung-Tsung Li, Jing-Shan Lin, Hurng-Yi Wang, Pei-Jer Chen and Ding-Shinn Chen. The role of hepatitis B virus surface and core antigens in determining the host immune responses against HBV. Poster Presentation. 2019 international HBV meeting: Mwelbourne, Australia. OCT 1~5, 2019.
3 Yung-Tsung Li, Chun-Jen Liu, Li-Ling Wu, Li-Feng Lin, Hui-Chu Tu, Pei-Jer Chen, Ding-Shinn Chen, Hui-Lin Wu. Metastatic tumor antigen 1, an HBx-interacting protein, stabilizes the 3' UTR of MYC RNA and protects it from let-7-mediated repression. Oral Presentation. 2019 international HBV meeting: Melbourne, Australia. OCT 1~5, 2019.
4 Li-Ling Wu, Wei-Hao Peng, Hui-Lin Wu, Shi-Chuen Miaw, Shiou-Hwei Yeh, Hung-Chih Yang, Pei-Hsuan Liao, Jing-Shan Lin, Yen-Tien Hong, Hurng-Yi Wang, Pei-Jer Chen and Ding-Shinn Chen. Ly6C+ Monocytes recruited via CCL2/CCR2 axis contribute to Age-dependent Hepatitis B Virus Clearance. Oral Presentation. 2018 international HBV meeting: Taormina, Italy. OCT 3~6, 2018.
5 Li-Ling Wu, Yen-Tien Hong, Chia-Hung Hsieh, Hurng-Yi Wang, Pei-Jer Chen and Ding-Shinn Chen. The role of liver macrophage against hepatitis B virus in age and gut microbiota-dependent HBV clearance. Poster Presentation. 2018 international HBV meeting: Taormina, Italy. OCT 3~6, 2018.
6 Li-Ling Wu, Yan-Rong Chen, Jing-Shan Lin, Pei-Hsuan Liao, Wei-Hao Peng, Hurng-Yi Wang, Hung-Chih Yang, Pei-Jer Chen and Ding-Shinn Chen. Hepatic macrophage plays a critical role in determining the age-dependent outcome of hepatitis B virus infection. Poster Presentation. 2017 international HBV meeting: Washington DC, U.S.A., Sep 3~Sep 7, 2017.
7 Li-Ling Wu, Jing Shan Lin, Pei-Hsuan Liao, Wei-Hao Peng, Hurng-Yi Wang, Pei-Jer Chen and Ding-Shinn Chen. Hepatic macrophage plays a critical role in determining the age-dependent outcome of hepatitis B virus infection. Oral Presentation. The 32th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2017.
8 Li-Ling Wu, Wei-Hao Peng, Wei-Ting Kuo, Ching-Ying Huang, Yen-Hsuan Ni, Kuo-Shyan Lu, Jerrold R. Turner, and Linda C.H. Yu. Interferon γ-induced bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning in bowel obstruction. Oral Presentation. The 30th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2015.
9 Yu-Chen Pai, Li-Ling Wu, Linda Chia-Hui Yu. Regulatory mechanisms of proinflammatory cytokine-induced bacterial endocytosis in intestinal epithelial cells. Poster Presentation. The 30th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2015.
10 Li-Ling Wu, Wei-Hao Peng, Wei-Ting Kuo, Ching-Ying Huang, Yen-Hsuan Ni, Kuo-Shyan Lu, Jerrold R. Turner, and Linda C.H. Yu. Interferon γ-induced bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning. Poster Presentation. Digestive disease week, Chicago, U.S.A. May 3~May 6, 2014.
11 Wei-Ting Kuo, Hsun-Yuan Yang, Chi-Yun Chen, Tsung-Chun Lee, Yen-Zhen Lu, Li-Ling Wu, John T Kung, Fuu Sheu, Yen-Hsuan Ni, Shu-chen Wei, Long-Wei Lin and Linda Chia-Hui Yu. Opposing roles of CD14 and TLR4 in bacterial LPS-induced colonocytic apoptosis. Poster Presentation. Digestive disease week, Chicago, U.S.A. May 3~May 6, 2014.
12 Wei-Ting Kuo, Hsun-Yuan Yang, Chi-Yun Chen, Tsung-Chun Lee, Yen-Zhen Lu, Li-Ling Wu, John T Kung, Fuu Sheu, Yen-Hsuan Ni, Shu-chen Wei, Long-Wei Lin and Linda Chia-Hui Yu. Antagonistic role of CD14 and TLR4 in colonic epithelial apoptosis induced by nonpathogenic bacterial lipopolysaccharide. Poster Presentation. The 29th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2014.
13 Li-Ling Wu, Wei-Hao Peng, Wei-Ting Kuo, Ching-Ying Huang, Yen-Hsuan Ni, Kuo-Shyan Lu, Jerrold R. Turner, and Linda C.H. Yu. Interferon γ-induced Bacterial Endocytosis in Epithelial Cells is Dependent on Myosin Light Chain Kinase-Activated Brush Border Fanning. Poster Presentation. The 29th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2014.
14 Li-Ling Wu, Wei-Ting Kuo, Wei-Hao Peng, Kuo-Shyan Lu, Yen-Hsuan Ni, Jerrold R. Turner and Linda Chia-Hui Yu. Intestinal epithelial endocytosis of commensal bacteria is dependent on IFNγ-induced terminal web myosin phosphorylation and brush border fanning. Poster Presentation. Experimental Biology. Boston, U.S.A. APR 20-24, 2013.
15 Li-Ling Wu, Wei-Ting Kuo, Wei-Hao Peng, Kuo-Shyan Lu, Yen-Hsuan Ni and Linda Chia-Hui Yu. Bowel Obstruction Triggers Commensal Bacterial endocytosis in epithelial cells: role of terminal web myosin and myosin light chain kinase. Oral Presentation. 4th world congress of pediatric gastroenterology, Hepatology and Nutrition. Taipei, Taiwan, Nov.14-18, 2012.
16 Linda Chia-Hui Yu, Yi-An Shih, Li-Ling Wu, Yen-Zhen Lu, Shu-Chen Wei,Yang-Ding Lin, and Yen-Hsuan Ni . Enteric dysbiosis and malfunctions in mice with antibiotic-resistant bacterial invasion. Oral Presentation. 4th world congress of pediatric gastroenterology, Hepatology and Nutrition. Taipei, Taiwan, Nov.14-18, 2012
17 Li-Ling Wu, Wei-Ting Kuo, Wei-Hao Peng, Kuo-Shyan Lu, Yen-Hsuan Ni and Linda Chia-Hui Yu. Intestinal epithelial endocytosis of commensal bacteria is dependent on phosphorylation of terminal web myosin by myosin light chain kinase in bowel obstruction. Oral Presentation. Digestive disease week, San Diego, U.S.A. May 22, 2012.
18 Li-Ling Wu, Wei-Ting Kuo and Linda Chia-Hui Yu. Bowel obstruction triggers bacterial endocytosis by enterocytes prior to paracellular bacterial flux: role of epithelial MLCK. Oral Presentation. The 27th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2012.
19 Li-Ling Wu, Wei-Ting Kuo and Linda Chia-Hui Yu. Bowel obstruction triggers bacterial endocytosis by enterocytes prior to paracellular bacterial flux: role of epithelial MLCK. Oral Presentation. The 27th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2012.
20 LiYi-An Shih, Li-Ling Wu, Yen-Zhen Lu, Wei-ting Kuo, Shin Chen, Shu-chen Wei, Yang-Ding Lin, Min-Jie Tsai, Yen-Hsuan Ni, Linda chia-Hui Yu. Antibiotic-induced enteric commensal dysbiosis favours superbug colonization and bacterial invasion in mice. Poster Presentation. The 27th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2012.
21 Shin chen, Tzu-Ling chen, Yen-Zhen Lu, Tsung-Chun Lee, Li-Ling Wu, Wei-Ting Kuo, Yi-An Shi, Chin-Hung Sun, Linda Chia-Hui Yu. Persistent gut inflammation and barrier dysfunction post-clearance of Giardia: implications for the pathogenesis of post-infectious irritable bowel syndrome. Oral Presentation. The 27th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2012.
22 Li-Ling Wu, Wei-Ting Kuo and Linda Chia-Hui Yu. Epithelial MLCK-dependent bacterial endocytosis by enterocytes precedes paracellular bacterial flux in bowel obstruction. Oral Presentation. Digestive disease week, Chicago, U.S.A. May 7~May 10, 2011.
23 Li-Ling Wu, Hsin-Da Chiu, Wei-Hao Peng, Bor-Ru Lin, Kuo-Shyan Lu, Yen-Zhen Lu, and Linda Chia-Hui Yu. Epithelial inducible nitric oxide synthase causes bacterial translocation by impairment of enterocytic tight junctions via intracellular signals of Rho-associated kinase and protein kinase C zeta. Poster Presentation.  Symposium on Frontiers of Biomedical Sciences. Taipei, ROC, August 18, 2011.
24 Li-Ling Wu, Wei-Ting Kuo and Linda Chia-Hui Yu. Bowel obstruction triggers bacterial endocytosis by enterocytes prior to paracellular bacterial flux: role of epithelial MLCK. Oral Presentation. The 26th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2011.
25 Li-Ling Wu, Hsin-Da Chiu, Yen-Zhen Lu, and Linda Chia-Hui Yu. Epithelial iNOS impairs tight junctions leading to bacterial translocation via PKCzeta activation and Rho/ROCK-dependent myosin light chain phosphorylation in obstructed guts. Oral Presentation. Digestive disease week, New Orleans, U.S.A. May 1~May 5, 2010.
26 Li-Ling Wu, Hsin-Da Chiu, Yen-Zhen Lu and Linda Chia-Hui Yu. Upregulation of epithelial iNOS and nitric oxide production leads to gut barrier defects and bacterial yranslocation: role of PKCzeta and Rho/ROCK signaling. Poster Presentation. The 25th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2010.
27 Hsun-Yuan Yang, Wei-Ting Kuo, Li-Ling Wu, Yen-Zhen Lu, Ching-Ying Huang and Linda Chia-Hui Yu. Role of CD14 and TLR4 in LPS-induced intestinal epithelial cell apoptosis in mice. Poster Presentation. The 25th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2010.
28 Li-Ling Wu, Ching-Ying Huang, Yen-Zhen Lu, and Linda Chia-Hui Yu. Epithelial MLCK and iNOS are involved in mucosal barrier defects and bacterial translocation induced by ileal obstruction. Poster Presentation. Digestive disease week, Chicago, U.S.A. May 30~June 4, 2009.
29 Li-Ling Wu, Ching-Ying Huang, Yen-Zhen Lu, and Linda Chia-Hui Yu. Ileal obstruction triggers bacterial translocation and mucosal barrier dysfunction: role of epithelial MLCK and iNOS. Poster Presentation. The 24th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2009.
30 Hsin-Da Chiu, Li-Ling Wu, Linda Chia-Hui Yu. Nitric oxide-induced intestinal epithelial barrier defects: role of tight junction disruption and myosin light chain phosphorylation. Poster Presentation. The 24th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2009.
31 Yih-Loong Lai and Li-Ling Wu, Mast cells, bradykinin (BK), and reactive oxygen species (ROS) in noncholinergic airway contriction. Poster Presentation. The 99th ATS internation conference, Seattle.U.S.A. May 16~May 21, 2003.
32 Li-Ling Wu and Yih-Loong Lai. Bradykinin and oxygen radicals in citric acid aerosol inhalation-induced bronchoconstriction of guinea pigs. Poster Presentation. The 19th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2002.
33 Li-Ling Wu and Yih-Loong Lai. Bradykinin and oxygen radicals in citric acid aerosol inhalation-induced bronchoconstriction of guinea pigs. Poster Presentation. The 19th Joint Annual Conference of Biomedical Science: Taipei, ROC, 2002.

專書

1 Li-Ling Wu, Hurng-Yi Wang, Pei-Jer Chen*. (2017) Hydrodynamic HBV Transfection Mouse Model. Hepatitis B Virus Methods and Protocols-Methods in Molecular Biology (ISBN: 978-1-4939-6698-1). New York, USA: Springer New York. Methods Mol Biol. 2017;1540: 227-235.
2 Yih-Loong Lai, Li-Ling Wu, L. C. Lai, Human respiration physiology, Gold name Book Publishers, ISBN:978-986-6575-88-4, Taipei, Taiwan, 2013
3 Yih-Loong Lai, Linda Chia-Hui Yu, Li-Ling Wu, Wan-fang Liu, Zi-Yin Chen, Shyh-Jong Wu, Medical Physiology, Ho-Chi Book Publishers, ISBN 978-986-157-570-4,Taipei, Taiwan, 2008
4 Yih-Loong Lai, Yuan-Feen Tsai, M. C. Hu, Li-Ling Wu, Ying-Jui Ho, Crown-State ZhuYi-lin Xie, Ya-Hui Ku, Wei-Yao Wang, Yi-Ren Wang, Human physiology: mechanisms of body function, Yi-Xuan Book Publishers, ISBN:986-157-252X,Taipei, Taiwan, 2006
5 Li-Ling Wu, Yi-lin Xie et al., New Medical Physiology (Revised Edition) Ho-Chi Book Publishers, ISBN 9812594647,Taipei, Taiwan, 2005
6 Li-Ling Wu, Crown-State Zhu, Ying-Jui Ho, Physiology Essentials, Yi-Xuan Book Publishers, ISBN 9576167108,Taipei, Taiwan, 2003
7 Li-Ling Wu, Ying-Jui Ho, Physiology proficient, Yi-Xuan Book Publishers, ISBN 9576166799,Taipei, Taiwan, 2002
 
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